Research

Microbes are essential for the integrity of environmental ecosystems and may be harnessed to provide sustainable and scalable solutions to the challenges posed by climate change and environmental degradation. Our group's research aims at better understanding how microbes and microbiomes function in order to, for example, provide insights into microbial processes underlying the marine carbon cycle and inform the engineering of microbes or microbiomes to provide sustainable solutions, from wastewater treatment to plastic degradation and CO2 sequestration. We often focus first on understanding fundamental processes at the level of single cells and then ask how the behavior of individual microbes and interactions between them gives rise to the function of microbial communities and entire microbial ecosystems. In our studies, we use microfluidics-based live-cell imaging and a variety of omics methods including genomics, transcriptomics and proteomics and metabolomics. We furthermore use bioinformatics approaches as well as mathematical and computational modeling to gain further mechanistic insights and to conceptualize our findings. To connect our work to tangible solutions for concrete problems, we collaborate with environmental physicists, chemists and engineers.

Microbial interactions at the microscale

Metabolic interactions in spatially structured microbial communities

Enlarged view: Two bacterial genotypes growing together in a microfluidic chamber

Microbial communities exhibit complex metabolic interactions. We investigate how these interactions arise at the single-cell level and scale up to determine community functions. Read more

Antagonism as a strategy for nutrient acquisition

Cells (blue) antagonising another strain (purple) to cause cell lysis and potentially nutrient release

We investigate antagonistic strategies employed by microbes to acquire nutrients from their neighbouring cells through cell lysis. Read more

Group behavior and collective nutrient breakdown

Cells colored according to their lineage, degrading a polymer as a group

Various tasks in microbial communities are performed collectively (e.g. polymer degradation or biofilm formation). We investigate how microbes coordinate group behaviour and how such behaviour evolves. Read more

Distribution of functions in microbiomes

Principles of metabolic pathway distribution

Cartoon of cells engaging in metabolite-mediated interactions

Microbial communities exhibit a collective metabolism. We investigate what drives the evolution of such distributed metabolism and what its ecological implications are. Read more

Stability and coexistence in microbial communities

Nutrient utilisation strategy

Many species that perform the same function or occupy the same niche coexist in microbial communities. We aim to understand how this redundancy is maintained and how it influences the resilience of the community. Read more

The ecology of phages within microbiomes

Phages in microbial communities

We are just starting to look deeper into the role of phages in microbial communities! Read more

Climate and enviromental solutions

Microbial and molecular approaches to tackle environmental challenges

Algal bloom in Baltic Sea

Microbes play key roles in biogeochemical cycles and biotechnological processes such as wastewater treatment. We are leveraging our fundamental research on microbial communities to address environmental degradation and climate change. Read more

Method development for microbial ecology

Microfluidics method and software development

kChip wells with droplets

To study microbial community function and organisation quantitatively, we develop microfluidics methods and image analysis software. Read more

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